Uric Acid Nephropathy Kidney Stones. A small stone may pass without causing symptoms. Uric acid is the relatively water insoluble end product of purine nucleotide metabolism.
It poses a special problem for humans because of its limited solubility particularly in the acidic environment of the distal nephron of the kidney. Hypoxanthine guanine phosphoribosyltransferase deficiency an x linked disorder is an infrequent cause of uric acid nephropathy and stone disease in boys. Red meat and shellfish have high concentrations of a natural chemical substance referred to as a purine.
A small stone may pass without causing symptoms.
It poses a special problem for humans because of its limited solubility particularly in the acidic environment of the distal nephron of the kidney. Uric acid stones cystine stones people should speak with their healthcare provider to work out which type of kidney stones they have had if any to support effective dietary choices. It poses a special problem for humans because of its limited solubility particularly in the acidic environment of the distal nephron of the kidney. High purine consumption results in a greater production of uric acid which then collects as crystals in the joints or as stones in the kidneys.