Uric Acid Excretion Kidney Stones. There is uncertainty about the relation between 24 h urinary uric acid excretion and the risk of calcium oxalate nephrolithiasis. Uric acid excretion may be reduced for several reasons which can cause an elevation in blood uric acid levels.
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For example compared with women with mean 24 h urine uric acid excretion 400 mg day 1 the multivariate relative risk of being a stone former in those with uric acid 800 mg day 1 was 0 16 0 04 0 60. Uric acid stones are one of four major types of kidney stones which include calcium stones calcium oxalate and calcium phosphate struvite stones and cystine stones. There is uncertainty about the relation between 24 h urinary uric acid excretion and the risk of calcium oxalate nephrolithiasis.
The low excretion of ammonium in patients with metabolic syndrome has been linked to more acidic urine and a higher incidence of uric acid stones.
24 h uric acid excretion and the risk of kidney stones gc curhan1 2 3 and en taylor1 2 1department of medicine renal division brigham and women s hospital harvard medical school boston massachusetts usa. Ketogenic diets certain drugs and some kidney diseases may be responsible. Uric acid excretion may be reduced for several reasons which can cause an elevation in blood uric acid levels. Defects in urinary acidification excretion of inappropriately alkaline or acidic urines respectively contribute to kidney stone disease.
